Episode 1 (Pilot): Ticks, and light-based mind control

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Hosts Lisl, Trisha, Diego, and David find the Michael Phelps of the tick world, present the new diet of the 21st century: light based mind control, and demonstrate that graduate students just aren’t great at winning trivia.

TICKS

Science Take: What makes Ticks Stick?

OPTOGENETICS

(based on “Lights” by Ellie Goulding)
You had a hunch that the PBN controls hunger
But what were the cells that could suppress appetite?
And I’m not hungry now, did you inject LPS?
And now you’ve found the cells, that start expressing c-fos

You turn the light on and my hunger’s gone
The light turns on my neurons
Just by activating channel-rhodopsin
Just in the CGRP

Now, I’m starving, starving, starving, but I
Don’t seem to notice at all
( You turned the light on and my hunger’s gone
I’m under its control

Fiberoptics implanted in my head
The laser shines through and lights up my neurons
And now I know just why my brother and my sister had
Calca-CRE transgenes, with GFP that glowed green

You turn the lights on and my hunger grows
You’re using halo rhodopisn
And you inhibit the CGRP neurons
I’m under it’s control

And I’m eating, eating, eating, can’t stop
Even though this food is gross
You turn the lights on and I’m ravenous
I’m under its control
Ohhh
Lights, lights, lights, lights
Lights, lights, lights, lights
Opto – optogenetics
Lights, lights, lights, lights
Lights, lights
You turn the lights on and I’m under control
Since you injected the virus
That expresses photo reactive channels
Just like Karl Deisseroth

Yes it’s shining, shining, shining, always
At a precise frequency
You shine the light that activates certain neurons
What a ground-breaking technique

(Opto, Optogenetics)
Lights, lights, lights, lights
Lights, lights, lights, lights
(Opto, Optogenetics)
Lights, lights, lights, lights
Lights, lights, lights, lights

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