Goggles Optional dresses up to the nines this week in celebration of the Oscars! Join Dave, Diego, Lisl, and Trisha for a John Travolta-fied huzzah of the week’s most exciting science news. We interview the founder of Science Exchange, Dr. Elizabeth Iorns, on entrepreneurship, creating a global marketplace, and reproducibility in science. Do you wish that you could eat infinite amounts of ice cream, and have some protection against diabetes? Have no fear, because there might be a SNP for that!